2-Amino-6-(1-piperidinyl)benzonitrile → 1-benzyl-N-[2-cyano-3-(1-piperidinyl)phenyl]1H-tetrazole-5-carboxamide

HRID 65983Notes

Reaction equation

HRID 65983 reaction equation
[CH2:1]([N:8]1[C:12]([C:13](Cl)=[O:14])=[N:11][N:10]=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:16][C:17]1[CH:24]=[CH:23][CH:22]=[C:21]([N:25]2[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]2)[C:18]=1[C:19]#[N:20]>>[CH2:1]([N:8]1[C:12]([C:13]([NH:16][C:17]2[CH:24]=[CH:23][CH:22]=[C:21]([N:25]3[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30]3)[C:18]=2[C:19]#[N:20])=[O:14])=[N:11][N:10]=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 127157252-Amino-6-(1-piperidinyl)benzonitrileHCID 204638761-benzyl-1H-tetrazole-5-carbonyl chloride

Product 1

HCID 227567991-benzyl-N-[2-cyano-3-(1-piperidinyl)phenyl]1H-tetrazole-5-carboxamide

Procedure

In a manner similar to Example I, 1-benzyl-1H-tetrazole-5-carbonyl chloride is condensed with 2-amino-6-(1-piperidinyl)benzonitrile to give 1-benzyl-N-[2-cyano-3-(1-piperidinyl)phenyl]-1H-tetrazole-5-carboxamide.

Sources & evidence

ORD record
ord-5f83015b6d2f4e7592e406f6381411b1
Source dataset
uspto-grants-1978_12
Patent number
US04129735

Reaction notes

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