2-Amino-6-(4-morpholinyl)benzamide → 1-benzyl-N-[2-carbamoyl-3-(4-morpholinyl)phenyl]1H-tetrazole-5-carboxamide

HRID 65985Notes

Reaction equation

HRID 65985 reaction equation
[CH2:1]([N:8]1[C:12]([C:13](Cl)=[O:14])=[N:11][N:10]=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:16][C:17]1[CH:25]=[CH:24][CH:23]=[C:22]([N:26]2[CH2:31][CH2:30][O:29][CH2:28][CH2:27]2)[C:18]=1[C:19]([NH2:21])=[O:20]>>[CH2:1]([N:8]1[C:12]([C:13]([NH:16][C:17]2[CH:25]=[CH:24][CH:23]=[C:22]([N:26]3[CH2:27][CH2:28][O:29][CH2:30][CH2:31]3)[C:18]=2[C:19](=[O:20])[NH2:21])=[O:14])=[N:11][N:10]=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 127523752-Amino-6-(4-morpholinyl)benzamideHCID 204638761-benzyl-1H-tetrazole-5-carbonyl chloride

Product 1

HCID 127523911-benzyl-N-[2-carbamoyl-3-(4-morpholinyl)phenyl]1H-tetrazole-5-carboxamide

Procedure

In a manner similar to Example I, 1-benzyl-1H-tetrazole-5-carbonyl chloride is condensed with 2-amino-6-(4-morpholinyl) benzamide to give 1-benzyl-N-[2-carbamoyl-3-(4-morpholinyl)phenyl]1H-tetrazole-5-carboxamide.

Sources & evidence

ORD record
ord-9e3cdf98e60840ac9b63d25e6edd1bdb
Source dataset
uspto-grants-1978_12
Patent number
US04129735

Reaction notes

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