1-(4-methoxybenzyl)-1H-tetrazole-5-carbonyl chloride → 1-(4-methoxybenzyl)-N-[2-cyano-3-(2-methyl-4-morpholinyl)phenyl]-1H-tetrazole-5-carboxamide

HRID 65986Notes

Reaction equation

HRID 65986 reaction equation
[CH3:1][O:2][C:3]1[CH:17]=[CH:16][C:6]([CH2:7][N:8]2[C:12]([C:13](Cl)=[O:14])=[N:11][N:10]=[N:9]2)=[CH:5][CH:4]=1.[NH2:18][C:19]1[CH:26]=[CH:25][CH:24]=[C:23]([N:27]2[CH2:32][CH2:31][O:30][CH:29]([CH3:33])[CH2:28]2)[C:20]=1[C:21]#[N:22]>>[CH3:1][O:2][C:3]1[CH:17]=[CH:16][C:6]([CH2:7][N:8]2[C:12]([C:13]([NH:18][C:19]3[CH:26]=[CH:25][CH:24]=[C:23]([N:27]4[CH2:32][CH2:31][O:30][CH:29]([CH3:33])[CH2:28]4)[C:20]=3[C:21]#[N:22])=[O:14])=[N:11][N:10]=[N:9]2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 204638701-(4-methoxybenzyl)-1H-tetrazole-5-carbonyl chlorideHCID 227568052-Amino-6-(2-methyl-4-morpholinyl)benzonitrile

Product 1

HCID 227567971-(4-methoxybenzyl)-N-[2-cyano-3-(2-methyl-4-morpholinyl)phenyl]-1H-tetrazole-5-carboxamide

Procedure

In a manner similar to Example I, 1-(4-methoxybenzyl)-1H-tetrazole-5-carbonyl chloride is condensed with 2-amino-6-(2-methyl-4-morpholinyl)benzonitrile to give 1-(4-methoxybenzyl)-N-[2-cyano-3-(2-methyl-4-morpholinyl)phenyl]-1H-tetrazole-5-carboxamide.

Sources & evidence

ORD record
ord-021c64ffafcd432eaced9a006bf61b07
Source dataset
uspto-grants-1978_12
Patent number
US04129735

Reaction notes

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