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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 659932Generated: October 30, 2026

Thionyl Chloride → 2,4-Dichloro-3-[2-(1H-tetrazol-1-yl)ethoxy]benzoyl chloride

https://huagongshe.com/reaction/659932

Reaction equation

Participants

RoleNameHCIDCharge
ReactantThionyl ChlorideHCID 24386—
Reactant2,4-Dichloro-3-[2-(1H-tetrazol-1-yl)ethoxy]benzoic acidHCID 57437270—
CatalystDimethylformamideHCID 6228—
Solvent1,2-DichloroethaneHCID 11—
Product2,4-Dichloro-3-[2-(1H-tetrazol-1-yl)ethoxy]benzoyl chlorideHCID 57437255100.4%

Reaction Steps

2,4-dichloro-3-[2-(1H-tetrazol-1-yl)ethoxy]benzoic acid (0.46 g) and thionyl chloride (0.36 g) were added in 1,2-dichloroethane (10 ml), two drops of DMF were added and the mixture was refluxed by heating for 3 hours. After cooling, the solvent was distilled off to obtain the desired 2,4-dichloro-3-[2-(1H-tetrazol-1-yl)ethoxy]benzoyl chloride (0.49 g).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08084398B2
Source datasetuspto-grants-2011_12
ORD IDord-59b7f4b5e21b46cea63560e22aade3c5
Source noteuspto-grants-2011_12