1,8-Diazabicyclo(5.4.0)undec-7-ene → HCID 58496628, compound

Participants

Reaction Steps

A solution of 1-[4-(trifluoromethyl)phenyl]butan-1-ol (1.4 , 6.4 mmol) and diphenylphosphoryl azide (2.8 ml, 12.8 mmol) in THF (6 mL) cooled to −10° C. under N2 was treated with DBU (1.9 mL, 12.8 mmol). The resulting solution was stirred at room temperature for 20 hours and then diluted with a mixture of ether and H2O. The organic phase was dried and concentrated and the residue purified by column chromatography using hexane:diethyl ethyl acetate (10:1) as eluent to furnish pure azide (0.85 g, 54%).

Provenance & Evidence