4,6-Dichloropyrimidine → HCID 86038803, compound

HRID 659998Notes

Reaction equation

HRID 659998 reaction equation
[CH2:1]([O:8][C:9]1[CH:15]=[CH:14][C:12]([NH2:13])=[CH:11][C:10]=1[N+:16]([O-:18])=[O:17])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:19][C:20]1[CH:25]=[C:24](Cl)[N:23]=[CH:22][N:21]=1>>[CH2:1]([O:8][C:9]1[CH:15]=[CH:14][C:12]([NH:13][C:24]2[CH:25]=[C:20]([Cl:19])[N:21]=[CH:22][N:23]=2)=[CH:11][C:10]=1[N+:16]([O-:18])=[O:17])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 709434,6-DichloropyrimidineHCID 58945262HCID 58945262, compound

Product 1

HCID 86038803HCID 86038803, compound

Procedure

The reaction of 4-benzyloxy-3-nitro-aniline with 4,6-dichloropyrimidine to afford 4-(4′benzyloxy-3-nitrophenyl)amino-6-chloro-pyrimidine is performed according to Preparation method 1. δH (d6DMSO): 5.34 (2H, s, CH2Ar), 6.84, (1H, s, HetH), 7.30-7.75 (7H, m, ArH), 8.30 (1H, m, ArH), 8.55 (1H, s, Het H), 10.10 (1H, s, NH)

Sources & evidence

ORD record
ord-1f6c51ac8e15487e89e5dedd8a9fffb1
Source dataset
uspto-grants-2011_12
Patent number
US08084457B2

Reaction notes

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