HCID 42639924, compound → HCID 42640083, compound

Participants

Reaction Steps

To a stirred solution of 5-fluoro-4-methyl-2-{4-methyl-1-[3-(1-methyl-piperidin-4-yl)-propyl]-2,3-dihydro-1H-indol-5-yl}-1H-benzoimidazole (40 mg, 0.10 mmol) in toluene (2 mL) was added MnO2 (44 mg, 0.51 mmol). After 1 h at 70° C., the mixture was cooled, filtered through diatamaceous earth, and concetrated. The crude residue was purified by FCC to give the title compound (35 mg, 84%). MS: mass calcd. for C26H31FN4, 418.25; m/z found, 421.3 [M+H]+. 1H NMR (CD3OD): 7.42-7.33 (m, 3H), 7.30 (d, J=3.2, 1H), 6.99 (dd, J=10.4, 8.7, 1H), 6.62 (d, J=2.7, 1H), 4.22 (t, J=6.9, 6.9, 2H), 2.86-2.78 (m, 2H), 2.65 (s, 3H), 2.50 (d, J=1.2, 3H), 2.22 (s, 3H), 2.00-1.83 (m, 4H), 1.73-1.56 (m, 2H), 1.31-1.11 (m, 5H).

Provenance & Evidence