HCID 68872593, compound → HCID 86631461, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-[3-(6-chloro-5-hydroxymethyl-indol-1-yl)-propyl]-piperidine-1-carboxylic acid tert-butyl ester (0.55 g, 1.35 mmol) and MnO2 (0.59 mg, 6.77 mmol) in toluene (10 mL) was heated at 100° C. for 30 min. The mixture was cooled to rt and filtered through diatomaceous earth. The filtrate was concentrated and used without further purification. MS: mass calcd. for C22H29ClN2O3, 404.19; m/z found, 405.4 [M+H]+.

Provenance & Evidence