HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazine, 1-propyl-, hydrochloride (1:2) → 2-(4'-Propylpiperazino)-5-oxo-6-carbethoxy-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazine, 1-propyl-, hydrochloride (1:2) | HCID 415812 | — |
| Reactant | 2-Chloro-5-oxo-6-carbethoxy-8-ethyl-5,8-dihydropyrido(2,3-d)pyrimidine | HCID 12266805 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 2-(4'-Propylpiperazino)-5-oxo-6-carbethoxy-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidine | HCID 22756840 | 84.6% |
Reaction Steps
As described in Example XII, the condensation of 2.8 g of 2-chloro-5-oxo-6-carbethoxy-8-ethyl-5,8-dihydropyrido(2,3-d)pyrimidine with 2.2 g of 1-propyl-piperazine, in chloroform (40 cm3) gives, after the treatments described in Example XII, 3.14 g of 2-(4'-propylpiperazino)-5-oxo-6-carbethoxy-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidine (yield 84%); melting point 149° C., after recrystallisation from ethyl acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04129737 |
| Source dataset | uspto-grants-1978_12 |
| ORD ID | ord-afaf807a19e14d4ba6b67437a2a92448 |
| Source note | uspto-grants-1978_12 |