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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 660070Generated: November 2, 2026

2-bromo-N-(pyrazin-2-yl)acetamide → (R)-3-Hydroxy-1-(pyrazin-2-ylcarbamoylmethyl)-1-azonia-bicyclo[2.2.2]octane bromide

https://huagongshe.com/reaction/660070

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-bromo-N-(pyrazin-2-yl)acetamideHCID 44542669—
Reactant(R)-3-Hydroxy-1-(isoxazol-3-ylcarbamoylmethyl)-1-azonia-bicyclo[2.2.2]octane bromideHCID 86627857—
Product(R)-3-Hydroxy-1-(pyrazin-2-ylcarbamoylmethyl)-1-azonia-bicyclo[2.2.2]octane bromideHCID 86627863—

Reaction Steps

This compound is prepared by an analogous method to (R)-3-hydroxy-1-(isoxazol-3-ylcarbamoylmethyl)-1-azonia-bicyclo[2.2.2]octane bromide (Intermediate A) by replacing 2-bromo-N-isoxazol-3-yl-acetamide with 2-bromo-N-pyrazin-2-yl-acetamide [H(i)].

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08084463B2
Source datasetuspto-grants-2011_12
ORD IDord-d6ff508bcfe144ae9a9a8d4a061abb35
Source noteuspto-grants-2011_12