HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Phenyl-1,2-oxazol-3-amine → (R)-3-Hydroxy-1-[(4-phenyl-isoxazol-3-ylcarbamoyl)-methyl]-1-azonia-bicyclo[2.2.2]octane bromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Phenyl-1,2-oxazol-3-amine | HCID 10773253 | — |
| Reactant | (R)-3-Hydroxy-1-(isoxazol-3-ylcarbamoylmethyl)-1-azonia-bicyclo[2.2.2]octane bromide | HCID 86627857 | — |
| Solvent | 3-Isoxazolamine | HCID 1810216 | — |
| Product | (R)-3-Hydroxy-1-[(4-phenyl-isoxazol-3-ylcarbamoyl)-methyl]-1-azonia-bicyclo[2.2.2]octane bromide | HCID 86627865 | — |
Reaction Steps
This compound is prepared by an analogous method to (R)-3-hydroxy-1-(isoxazol-3-ylcarbamoylmethyl)-1-azonia-bicyclo[2.2.2]octane bromide (Intermediate A) by replacing in 3-aminoisoxazol in step (Ai) with 4-phenylisoxazol-3-ylamine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08084463B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-01f771191443478788cfafbfd448d34b |
| Source note | uspto-grants-2011_12 |