HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydroxy-(4-methoxy-phenyl)-phenyl-acetic acid → Hydroxy-(4-methoxy-phenyl)-phenyl-acetic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydroxy-(4-methoxy-phenyl)-phenyl-acetic acid | HCID 231899 | — |
| Reactant | Hydroxy-bis-(3-methoxyphenyl)acetic acid | HCID 585026 | — |
| Reactant | Hydroxy-bis-(3-methoxy-phenyl)-acetic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester | HCID 86627867 | — |
| Product | Hydroxy-(4-methoxy-phenyl)-phenyl-acetic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester | HCID 86627868 | — |
Reaction Steps
This compound is prepared by an analogous method to hydroxy-bis-(3-methoxy-phenyl)-acetic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester (Intermediate K) by replacing hydroxy-bis-(3-methoxy-phenyl)-acetic acid (Intermediate J) with hydroxy-(4-methoxy-phenyl)-phenyl-acetic acid (Intermediate L).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08084463B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-4903f37313b84c86a1df3cc2b82ba723 |
| Source note | uspto-grants-2011_12 |