HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydroxy-phenyl-o-tolyl-acetic acid → Hydroxy-phenyl-o-tolyl-acetic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydroxy-phenyl-o-tolyl-acetic acid | HCID 226676 | — |
| Reactant | Hydroxy-bis-(3-methoxyphenyl)acetic acid | HCID 585026 | — |
| Reactant | Hydroxy-bis-(3-methoxy-phenyl)-acetic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester | HCID 86627867 | — |
| Product | Hydroxy-phenyl-o-tolyl-acetic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester | HCID 86627869 | — |
Reaction Steps
This compound is prepared by an analogous method to hydroxy-bis-(3-methoxy-phenyl)-acetic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester (Intermediate K) by replacing hydroxy-bis-(3-methoxy-phenyl)-acetic acid (Intermediate J) with hydroxy-phenyl-o-tolyl-acetic acid (Intermediate M).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08084463B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-8c2dc7304eec4463aa0b2ddde873737a |
| Source note | uspto-grants-2011_12 |