HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chlorobenzylpiperazine → 2-(4'-p-Chlorobenzyl-piperazino)-5-oxo-6-carbethoxy-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chlorobenzylpiperazine | HCID 134826 | — |
| Reactant | 2-Chloro-5-oxo-6-carbethoxy-8-ethyl-5,8-dihydropyrido(2,3-d)pyrimidine | HCID 12266805 | — |
| Product | 2-(4'-p-Chlorobenzyl-piperazino)-5-oxo-6-carbethoxy-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidine | HCID 12266809 | 74% |
Reaction Steps
Condensation of 1-p-chlorobenzyl-piperazine with 2-chloro-5-oxo-6-carbethoxy-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidine, as described in Example VII, gives, in a yield of 74%, 2-(4'-p-chlorobenzyl-piperazino)-5-oxo-6-carbethoxy-8-ethyl-5,8-dihydro-pyrido(2,3-d)pyrimidine; melting point 150° C., after recrystallisation from ethyl acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04129737 |
| Source dataset | uspto-grants-1978_12 |
| ORD ID | ord-52353e447c8043f5952fcb5206d578ee |
| Source note | uspto-grants-1978_12 |