HRID660095

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID13362919

2-Bromo-N-(1,2-oxazol-3-yl)acetamide

C5H5BrN2O2

结构：COc1ccc(C(O)(C(=O)O[C@H]2CN3CCC2CC3)c2ccccc2)cc1

HCID86627868

未命名化合物

2 次

PRODUCTS

生成物

结构：COc1ccc(C(O)(C(=O)O[C@H]2C[N+]3(CC(=O)Nc4ccon4)CCC2CC3)c2ccccc2)cc1.[Br-]

HCID11671405

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6212

Chloroform

CHCl3

2 次

CONDITIONS

反应条件

温度: 50 °C

PROCEDURE

实验过程

To a stirred solution of bromo-N-isoxazol-3-yl-acetamide (Intermediate Ai) (0.057 g, 0.278 mmol) in dry chloroform (1 ml) heated to 50° C. is added hydroxy-(4-methoxy-phenyl)-phenyl-acetic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl)ester (Intermediate O) in chloroform (1 ml). The reaction mixture is stirred at 50° C. for 6 hours after which time, the titled product is detected by LC-MS. (M+ 492.3)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f973b73ed66d4e39a63b4d639b637e15
来源数据集: uspto-grants-2011_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08084463B2
来源说明: uspto-grants-2011_12

反应 SMILES

[Br:1][CH2:2][C:3]([NH:5][C:6]1[CH:10]=[CH:9][O:8][N:7]=1)=[O:4].[N:11]12[CH2:18][CH2:17][CH:14]([CH2:15][CH2:16]1)[C@@H:13]([O:19][C:20](=[O:37])[C:21]([OH:36])([C:28]1[CH:33]=[CH:32][C:31]([O:34][CH3:35])=[CH:30][CH:29]=1)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[CH2:12]2>C(Cl)(Cl)Cl>[Br-:1].[OH:36][C:21]([C:28]1[CH:33]=[CH:32][C:31]([O:34][CH3:35])=[CH:30][CH:29]=1)([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[C:20]([O:19][C@@H:13]1[CH:14]2[CH2:15][CH2:16][N+:11]([CH2:2][C:3](=[O:4])[NH:5][C:6]3[CH:10]=[CH:9][O:8][N:7]=3)([CH2:18][CH2:17]2)[CH2:12]1)=[O:37]