HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Pyridinecarbonyl chloride, hydrochloride (1:1) → 1-(Pyridin-3-yl)heptan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Pyridinecarbonyl chloride, hydrochloride (1:1) | HCID 88438 | — |
| Reactant | Methoxy-methyl amide | HCID 53630747 | — |
| Reactant | HCID 178506865 | HCID 178506865 | — |
| Product | 1-(Pyridin-3-yl)heptan-1-one | HCID 222709 | — |
Reaction Steps
In an example of the general procedure (scheme 1), nicotinoyl chloride hydrochloride (1) is converted to the N-methyl-N-methoxyamide (2) in the presence of a base and reacted with hexyl-lithium (J. Med. Chem., 35, 1992, 2392-2406) to produce 1-pyridin-3-yl-heptan-1-one (3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08084473B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-e539eadc30454b1f98a367b86cc3d6a6 |
| Source note | uspto-grants-2011_12 |