HCID 178503312, compound → HCID 178480259, compound

HRID 660146Notes

Reaction equation

HRID 660146 reaction equation
[F:1][C:2]([F:19])([F:18])[CH2:3][CH2:4][CH2:5][S:6][C:7]1[C:8]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)=[N:9][NH:10][CH:11]=1.[CH3:20]SC1C(C2C=NC=CC=2)=NNC=1>>[F:19][C:2]([F:1])([F:18])[CH2:3][CH2:4][CH2:5][S:6][C:7]1[C:8]([C:12]2[CH2:13][N:14]([CH3:20])[CH2:15][CH2:16][CH:17]=2)=[N:9][NH:10][CH:11]=1

Participants

3

Reactant 2

HCID 178503312HCID 178503312, compoundHCID 178506318HCID 178506318, compound

Product 1

HCID 178480259HCID 178480259, compound

Procedure

Compound 21B (0.3 g, 1.49 mmol) was converted to compound 22B, using the methodology described for the conversion of 21A to 22A. Yield 0.131 g (amorphous, 72% overall). LCMS (method A); Rt: 1.64 min, ([M+H]+=306). 1H-NMR (400 MHz, CDCl3): δ 7.57 (s, 1H), 6.67-6.60 (bs, 1H), 3.43-3.39 (m, 2H), 2.71-2.62 (m, 4H), 2.49 (s, 3H), 2.48-2.43 (m, 2H), 2.28-2.19 (m, 2H), 1.81-1.75 (m, 2H).

Sources & evidence

ORD record
ord-e395c8891e8d46a9bca6baade0822cc1
Source dataset
uspto-grants-2011_12
Patent number
US08084473B2

Reaction notes

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