2,4-Difluorophenol → Methyl 5-chloro-2-[(2,4-difluorophenoxy)methyl]benzoate

HRID 660212Notes

Reaction equation

HRID 660212 reaction equation
BrC[CH2:3][C:4]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][C:5]=1[C:6]([O:8][CH3:9])=[O:7].[F:15][C:16]1[CH:21]=[C:20]([F:22])[CH:19]=[CH:18][C:17]=1[OH:23]>>[Cl:14][C:11]1[CH:12]=[CH:13][C:4]([CH2:3][O:23][C:17]2[CH:18]=[CH:19][C:20]([F:22])=[CH:21][C:16]=2[F:15])=[C:5]([CH:10]=1)[C:6]([O:8][CH3:9])=[O:7]

Participants

3

Reactant 2

HCID 1230512,4-DifluorophenolHCID 68983888Methyl 2-(bromoethyl)-5-chlorobenzoate

Product 1

HCID 68862490Methyl 5-chloro-2-[(2,4-difluorophenoxy)methyl]benzoate

Procedure

The title compound was prepared according to the procedure described in step 1 of Example 1 from methyl 2-(bromoethyl)-5-chlorobenzoate and 2,4-difluorophenol:

Sources & evidence

ORD record
ord-089dd52288ad4e60b13456f053ff1af8
Source dataset
uspto-grants-2011_12
Patent number
US08084476B2

Reaction notes

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