2,6-Difluorophenol → Methyl 5-chloro-2-[(2,6-difluorophenoxy)methyl]benzoate

HRID 660216Notes

Reaction equation

HRID 660216 reaction equation
BrC[CH2:3][C:4]1[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][C:5]=1[C:6]([O:8][CH3:9])=[O:7].[F:15][C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([F:22])[C:17]=1[OH:23]>>[Cl:14][C:11]1[CH:12]=[CH:13][C:4]([CH2:3][O:23][C:17]2[C:16]([F:15])=[CH:21][CH:20]=[CH:19][C:18]=2[F:22])=[C:5]([CH:10]=1)[C:6]([O:8][CH3:9])=[O:7]

Participants

3

Reactant 2

HCID 943922,6-DifluorophenolHCID 68983888Methyl 2-(bromoethyl)-5-chlorobenzoate

Product 1

HCID 68863358Methyl 5-chloro-2-[(2,6-difluorophenoxy)methyl]benzoate

Procedure

The title compound was prepared according to the procedure described in step 1 of Example 1 from methyl 2-(bromoethyl)-5-chlorobenzoate and 2,6-difluorophenol:

Sources & evidence

ORD record
ord-2e7ca5d046444782a625fd65742c443d
Source dataset
uspto-grants-2011_12
Patent number
US08084476B2

Reaction notes

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