(S)-Methyl 4-(1-aminoethyl)benzoate hydrochloride → Methyl 4-((1S)-1-{[5-chloro-2-(isobutoxymethyl)benzoyl]amino)ethyl}benzoate

HRID 660231Notes

Reaction equation

HRID 660231 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:11][O:12][CH2:13][CH:14]([CH3:16])[CH3:15])=[C:6]([CH:10]=1)[C:7]([OH:9])=O.Cl.[NH2:18][C@H:19]([C:21]1[CH:30]=[CH:29][C:24]([C:25]([O:27][CH3:28])=[O:26])=[CH:23][CH:22]=1)[CH3:20]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:11][O:12][CH2:13][CH:14]([CH3:16])[CH3:15])=[C:6]([CH:10]=1)[C:7]([NH:18][C@H:19]([C:21]1[CH:30]=[CH:29][C:24]([C:25]([O:27][CH3:28])=[O:26])=[CH:23][CH:22]=1)[CH3:20])=[O:9]

Participants

3

Reactant 2

HCID 57462942(S)-Methyl 4-(1-aminoethyl)benzoate hydrochlorideHCID 688636975-Chloro-2-(isobutoxymethyl)benzoic acid

Product 1

HCID 68862836Methyl 4-((1S)-1-{[5-chloro-2-(isobutoxymethyl)benzoyl]amino)ethyl}benzoate

Procedure

The title compound was prepared according to the procedure described in step 6 of Example 1 from 5-chloro-2-(isobutoxymethyl)benzoic acid (step 1) and methyl 4-[(1S)-1-aminoethyl]benzoate hydrochloride (step 5 of Example 1):

Sources & evidence

ORD record
ord-eba4a09024724fb39d1b1415b6722da5
Source dataset
uspto-grants-2011_12
Patent number
US08084476B2

Reaction notes

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