反应详情

Methyl-2-(4-hydroxyphenyl)acetate (2.0 g, 12.0 mmol) was dissolved in acetic acid (15 ml) and nitric acid (60-62%, 1.27 g, 12.1 mmol) was added at RT. The reaction mixture was stirred for 30 minutes at RT, poured into ice water (100 ml) and extracted with EA. The organic phase was dried over MgSO4, the solvent removed under a vacuum and the residue purified by means of column chromatography (n-hexane/EA=4:1).

1. extractionextracted with EA
2. dry with materialThe organic phase was dried over MgSO4
3. customthe solvent removed under a vacuum
4. customthe residue purified by means of column chromatography (n-hexane/EA=4:1)