反应详情

Methyl-2-(3-amino-4-hydroxyphenyl)acetate (1.39 g, 7.67 mmol) was combined at RT with triethyl orthoformate (10 ml). The reaction mixture was heated to reflux for 12 h and then cooled to RT. Water (70 mL) was added thereto and the reaction mixture was extracted with EA. The combined organic phases were dried over MgSO4 and filtered. The solvent was removed under a vacuum and the residue purified by means of column chromatography (n-hexane/EA=2:1).

1. temperatureThe reaction mixture was heated
2. temperatureto reflux for 12 h
3. extractionthe reaction mixture was extracted with EA
4. dry with materialThe combined organic phases were dried over MgSO4
5. filtrationfiltered
6. customThe solvent was removed under a vacuum
7. customthe residue purified by means of column chromatography (n-hexane/EA=2:1)