HuagongsheHuagongshe Chemistry Print Report · For research reference only
Nitric Acid → 4-amino-3-nitrophenylPropanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Nitric Acid | HCID 944 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | 4-Aminohydratropic acid | HCID 43026 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 4-amino-3-nitrophenylPropanoic acid | HCID 12226817 | — |
Reaction Steps
A solution of 2-(4-Aminophenyl)propanoic acid (8.45 g, 51.2 mmol) in AcOH (70 mL) was added HNO3 (60%, 5.66 g) at room temperature. The reaction mixture was refluxed for 4 hrs then cooled to room temperature. The mixture was poured into iced water (200 mL), and extracted with CH2Cl2. The organic layer was dried over MgSO4, filtered, and concentrated in vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08084484B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-19d595998b3a4f71862231140536bfd5 |
| Source note | uspto-grants-2011_12 |