反应详情

温度

50 °C

Ethyl 2-(4-hydroxyphenyl)propanoate (275 mg, 1.42 mmol) in acetic acid (2 mL) was added nitric acid (60-62%, 300 mg, 2.86 mmol) at room temperature. The mixture was stirred for 1 hour at 50° C. and cooled to room temperature. The reaction mixture was poured into ice water (20 mL) and extracted with EtOAc. The organic layer was dried with MgSO4 and filtered. EtOAc was removed by evaporation. The residue was purified by column chromatography eluting with n-Hexane/EtOAc=6/1.

1. temperaturecooled to room temperature
2. extractionextracted with EtOAc
3. dry with materialThe organic layer was dried with MgSO4
4. filtrationfiltered
5. customEtOAc was removed by evaporation
6. customThe residue was purified by column chromatography
7. washeluting with n-Hexane/EtOAc=6/1