反应详情

温度

50 °C

Ethyl 2-(3,4-dihydro-3-oxo-2H-benzo[b][1,4]oxazin-6-yl)propanoate (63 mg, 0.253 mmol) in 90% aq. EtOH (4.5 mL) was added sodium hydroxide (50 mg, 1.25 mmol) at room temperature. The reaction mixture was stirred for 12 hours at 50° C. and cooled to room temperature. The mixture was added water (20 mL) and acidified with acetic acid. The mixture was extracted with methylene chloride. The organic layer was dried with MgSO4 and filtered. The filtrate was concentrated in vacuo.

1. temperaturecooled to room temperature
2. extractionThe mixture was extracted with methylene chloride
3. dry with materialThe organic layer was dried with MgSO4
4. filtrationfiltered
5. concentrationThe filtrate was concentrated in vacuo