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HRID66033

反应详情

EQUATION

反应方程式

HRID 66033 的结构方程式

REACTANTS

反应物

3
结构：Nc1ccc(S(=O)(=O)O)c2cc(S(=O)(=O)O)cc(O)c12
HCID67224

4-Amino-5-hydroxynaphthalene-1,7-disulphonic acid

C10H9NO7S2

结构：Cc1ccc([N+](=O)[O-])cc1C(=O)Cl
HCID4436568

2-methyl-5-nitrobenzoyl chloride

C8H6ClNO3

结构：CC(=O)[O-].O.O.O.[Na+]
HCID23665404

Acetic acid, sodium salt, trihydrate

C2H9NaO5

PRODUCTS

生成物

1
结构：Cc1cc([N+](=O)[O-])ccc1C(=O)Nc1ccc(S(=O)(=O)O)c2cc(S(=O)(=O)O)cc(O)c12
HCID56996136

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

A 16 g portion of 4-amino-5-hydroxy-1,7-naphthalenedisulfonic acid in 120 ml of water is adjusted to pH7.2. A 7.6 g portion of sodium acetate trihydrate and 8.8 g of 2-methyl-5-nitrobenzoyl chloride are added with vigorous stirring. The mixture is stirred overnight at room temperature. The solid is then collected by filtration, washed with water, 80% ethanol, ethanol, ether and dried, giving 13.0 g of 5-hydroxy-4-(5-nitro-o-toluamido)-1,7-naphthalenedisulfonic acid, disodium salt.

WORKUP

后处理

  1. filtrationThe solid is then collected by filtration
  2. washwashed with water, 80% ethanol, ethanol, ether
  3. customdried