HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyanogen Bromide → 2-(2-Amino-5-benzoxazolyl) propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyanogen Bromide | HCID 10476 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 12202637 | HCID 12202637 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-(2-Amino-5-benzoxazolyl) propionic acid | HCID 53872031 | — |
Reaction Steps
A mixture of (2) (630 mg, 1 mmol) in H2O (33 ml) was added BrCN (383 mg, 1.04 mmol) at room temperature. The reaction mixture is stirred for 40 h at room temperature. The reaction mixture is neutralized to pH 6□7 with 40% aq. NaOH and filtered. The solid was recrystallized with 50% aq. MeOH and filtered. The solid is dried under vacuum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08084484B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-b5974317e8f0408399c9859a5e992f7c |
| Source note | uspto-grants-2011_12 |