HRID66034

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Nc1cc(S(=O)(=O)[O-])cc2cc(S(=O)(=O)[O-])cc(S(=O)(=O)[O-])c12.[Na+].[Na+].[Na+]

HCID101899

Trisodium 8-aminonaphthalene-1,3,6-trisulphonate

C10H6NNa3O9S3

结构：O=C(OC(=O)c1cccc([N+](=O)[O-])c1S(=O)(=O)O)c1cccc([N+](=O)[O-])c1S(=O)(=O)O

HCID15120080

未命名化合物

HCID23665404

Acetic acid, sodium salt, trihydrate

C2H9NaO5

PRODUCTS

生成物

结构：O=C(Nc1cc(S(=O)(=O)[O-])cc2cc(S(=O)(=O)[O-])cc(S(=O)(=O)[O-])c12)c1cccc([N+](=O)[O-])c1S(=O)(=O)O.[Na+].[Na+].[Na+].[Na+]

HCID131711372

未命名化合物

收率 353.6%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

2 次

PROCEDURE

实验过程

To a solution of 20.0 g of 8-amino-1,3,6-naphthalenetrisulfonic acid trisodium salt and 8.75 g of sodium acetate trihydrate in 180 ml of water at room temperature is added 12.0 g of 3-nitrosulfobenzoic anhydride with stirring. A 400 ml portion of water is added. The mixture is stirred at room temperature for 21/2 hours and then filtered. The filtrate is cooled, acidified with 2-3 ml of concentrated hydrochloric acid an diluted with ethanol. The pink solid is collected by filtration, washed with 85% ethanol, ether and dried. The filtrate is concentrated to a low volume and diluted with ethanol giving a second crop which is collected and combined with the first crop giving a total of 27.6 g of 8-(3-nitro-2-sulfobenzamido)-1,3,6-naphthalene trisulfonic acid tetrasodium salt.

WORKUP

后处理

stirringThe mixture is stirred at room temperature for 21/2 hours
filtrationfiltered
temperatureThe filtrate is cooled
additionan diluted with ethanol
filtrationThe pink solid is collected by filtration
washwashed with 85% ethanol, ether
customdried
concentrationThe filtrate is concentrated to a low volume
additiondiluted with ethanol giving a second crop which
customis collected

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8d7f49324533496f98d5befcfa55d907
来源数据集: uspto-grants-1978_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04129590
来源说明: uspto-grants-1978_12

反应 SMILES

[Na+:1].[Na+].[Na+].[NH2:4][C:5]1[CH:6]=[C:7]([S:23]([O-:26])(=[O:25])=[O:24])[CH:8]=[C:9]2[C:14]=1[C:13]([S:15]([O-:18])(=[O:17])=[O:16])=[CH:12][C:11]([S:19]([O-:22])(=[O:21])=[O:20])=[CH:10]2.O.O.O.C([O-])(=O)C.[Na+].[N+](C1C(S(O)(=O)=O)=C(C=CC=1)C([O:43][C:44](=O)[C:45]1[CH:50]=[CH:49][CH:48]=[C:47]([N+:51]([O-:53])=[O:52])[C:46]=1[S:54]([OH:57])(=[O:56])=[O:55])=O)([O-])=O>O>[Na+:1].[Na+:1].[Na+:1].[Na+:1].[N+:51]([C:47]1[C:46]([S:54]([OH:57])(=[O:55])=[O:56])=[C:45]([CH:50]=[CH:49][CH:48]=1)[C:44]([NH:4][C:5]1[CH:6]=[C:7]([S:23]([O-:26])(=[O:25])=[O:24])[CH:8]=[C:9]2[C:14]=1[C:13]([S:15]([O-:18])(=[O:17])=[O:16])=[CH:12][C:11]([S:19]([O-:22])(=[O:20])=[O:21])=[CH:10]2)=[O:43])([O-:53])=[O:52]