反应详情

Methyl 2-amino-3-pyridine carboxylate (15.2 grams; 0.1 mole), calcium carbonate (13.0 grams; 0.1 mole) and methylsulfamoyl chloride (13.0 grams; 0.1 mole) were mixed with 200 ml of acetonitrile and the resulting reaction mixture stirred at ambient temperatures for a period of about 15 hours. Following the reaction period, the reaction mixture was filtered and the solvent removed in vacuo. The semi-solid residue thus obtained was extracted with ethanol. A white crystalline precipitate, obtained by filtering the extract solution, was recrystallized from ethanol and the desired title compound having a melting point of 133° C.-139° C. was obtained.

1. customthe resulting reaction mixture
2. customthe reaction period
3. filtrationthe reaction mixture was filtered
4. customthe solvent removed in vacuo
5. customThe semi-solid residue thus obtained
6. extractionwas extracted with ethanol
7. customA white crystalline precipitate, obtained
8. filtrationby filtering the extract solution
9. customwas recrystallized from ethanol
10. customwas obtained