2-Aminopyridine → N-Pyridin-2-yl-N'-1,2,3-thiadiazol-5-ylurea

HRID 66048Notes

Reaction equation

HRID 66048 reaction equation
O([C:8]([NH:10][C:11]1[S:15][N:14]=[N:13][CH:12]=1)=[O:9])C1C=CC=CC=1.[NH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1>CC(C)=O>[N:18]1[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=1[NH:16][C:8]([NH:10][C:11]1[S:15][N:14]=[N:13][CH:12]=1)=[O:9]

Participants

4

Reactant 2

HCID 104392-AminopyridineHCID 320280MLS003107275

Product 1

HCID 20233425N-Pyridin-2-yl-N'-1,2,3-thiadiazol-5-ylurea

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

16.5 g (0.075 mol) 5-phenoxycarbonylamino-1,2,3-thiadiazole are suspended in 150 ml acetone and reacted with 9.4 g (0.1 mol) of 2-aminopyridine. The reaction mass is then refluxed for 3 hours. After cooling to room temperature the formed light brown crystals are removed by suction and dried. They are then recrystallized from ethanol. There is thus obtained the above noted title compound (compound No. 1).

Workup

  1. temperatureThe reaction mass is then refluxed for 3 hours
  2. customare removed by suction
  3. customdried
  4. customThey are then recrystallized from ethanol

Sources & evidence

ORD record
ord-9cd989bd400d4486b4cc1ba3d1381258
Source dataset
uspto-grants-1978_12
Patent number
US04130414

Reaction notes

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