5-(2-Benzyloxy-4-iodophenyl)-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one → HCID 68838915, compound

HRID 660497Notes

Reaction equation

HRID 660497 reaction equation
[CH2:1]([O:8][C:9]([N:11]1[CH:15]=[C:14]([CH:16]=[CH2:17])[CH:13]=[N:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:18]([O:25][C:26]1[CH:31]=[C:30](I)[CH:29]=[CH:28][C:27]=1[N:33]1[S:37](=[O:39])(=[O:38])[N:36]([CH2:40][CH2:41][Si:42]([CH3:45])([CH3:44])[CH3:43])[C:35](=[O:46])[CH2:34]1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[CH2:1]([O:8][C:9]([N:11]1[CH:15]=[C:14]([CH:16]=[CH:17][C:30]2[CH:29]=[CH:28][C:27]([N:33]3[CH2:34][C:35](=[O:46])[N:36]([CH2:40][CH2:41][Si:42]([CH3:45])([CH3:44])[CH3:43])[S:37]3(=[O:39])=[O:38])=[C:26]([O:25][CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH:31]=2)[CH:13]=[N:12]1)=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1.[CH2:18]([O:25][C:26]1[CH:31]=[C:30]([CH:17]=[CH:16][C:14]2[CH:15]=[N:11][NH:12][CH:13]=2)[CH:29]=[CH:28][C:27]=1[N:33]1[S:37](=[O:39])(=[O:38])[N:36]([CH2:40][CH2:41][Si:42]([CH3:45])([CH3:44])[CH3:43])[C:35](=[O:46])[CH2:34]1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

4

Reactant 2

HCID 667569375-(2-Benzyloxy-4-iodophenyl)-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-oneHCID 68840651Phenylmethyl 4-ethenyl-1H-pyrazole-1-carboxylate

Product 2

HCID 68838915HCID 68838915, compoundHCID 68839123HCID 68839123, compound

Procedure

The title compound is prepared from 4-vinylpyrazole-1-carboxylic acid benzyl ester and 5-(2-benzyloxy-4-iodophenyl)-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one analogous to Example 39, step D. The deprotected pyrazole, 5-{2-benzyloxy-4-[2-(1H-pyrazol-4-yl)-vinyl]-phenyl}-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one, is also isolated.

Sources & evidence

ORD record
ord-ae2b0e7d76674c7ab8ca9c4501ffa9db
Source dataset
uspto-grants-2011_12
Patent number
US08084448B2

Reaction notes

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