Methyl iodide → HCID 68843653, compound

Participants

Reaction Steps

A mixture of 5-{2-benzyloxy-4-[2-(1H-pyrazol-4-yl)-vinyl]-phenyl}-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one (example 40, step C) (114 mg, 0.224 mmol), MeI (0.05 mL, 0.80 mmol) and K2CO3 (60 mg, 0.43 mmol) in CH3CN (3 mL) is stirred at RT for 2 days. The mixture is partitioned between EtOAc and aq. NaHCO3. The organic phase is dried over MgSO4 and concentrated to afford the crude product.

Provenance & Evidence