Isocyanate → HCID 68839001, compound

Participants

Reaction Steps

Tetrabutylammonium fluoride (1.0M in THF, 2 mL) is added to a solution of PS-isocyanate resin (0.5 g) in THF (2 mL) and the mixture is stirred at RT for 2 h. The resin is filtered off and the filtrate is added to a solution of 5-[2-benzyloxy-4-((E)-3-phenylpropenyl)-phenyl]-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one (89 mg, 0.163 mmol) in THF (1 mL). The reaction is stirred at 75° C. for 1 h then the mixture is cooled and concentrated. The residue is partitioned between EtOAc and water and the organic layer is washed with 2N HCl (3×) and brine. The organic layer is dried over sodium sulfate and the solvent removed under reduced pressure to afford the title compound as a light yellow foam: (M−1)−=433.

Provenance & Evidence