Hydrochloric Acid → HCID 68842563, compound

Participants

Reaction Steps

To a solution of 5-[2-benzyloxy-4-(tert-butyldimethylsilanyloxy)phenyl]-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one (100 mg, 0.18 mmol) in THF (4.5 mL) is added 0.5 mL of 4N HCl in dioxane and the mixture is stirred at RT for 5 days. The solution is concentrated, dissolved in EtOAc and the aqueous phase separated. The organic phase is dried over magnesium sulfate and the solvent removed under reduced pressure to afford the title compound: 1H NMR (CDCl3δ7.29 (m, 5H), 7.16 (d, J=8.3 Hz, 1H), 6.42 (d, J=2.5 Hz, 1H), 6.27 (dd, J=8.3, 2.5 Hz, 1H), 4.92 (s, 2H), 4.24 (s, 2H), 3.52 (m, 2H), 0.99 (m. 2H), 0.00 (s, 9H): (M+1)+=435.

Provenance & Evidence