Sodium Hydroxide → Ampicillin Sodium

HRID 66053Notes

Reaction equation

HRID 66053 reaction equation
[CH3:1][C:2]1([CH3:24])[S:6][C@@H:5]2[C@H:7]([NH:10][C:11]([C@H:13]([NH2:20])[C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)=[O:12])[C:8](=[O:9])[N:4]2[C@H:3]1[C:21]([OH:23])=[O:22].O.O.O.[OH-].[Na+:29]>O>[CH3:1][C:2]1([CH3:24])[S:6][C@@H:5]2[C@H:7]([NH:10][C:11]([C@H:13]([NH2:20])[C:14]3[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=3)=[O:12])[C:8](=[O:9])[N:4]2[C@H:3]1[C:21]([O-:23])=[O:22].[Na+:29]

Participants

4

Reactant 2

HCID 14798Sodium Hydroxide2×HCID 23565Ampicillin Trihydrate

Product 1

HCID 23663979Ampicillin Sodium

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A suspension of 24.18 gm (60 millimols) of ampicillin trihydrate in 140 ml of water was admixed with 55.2 ml of an aqueous 1N sodium hydroxide solution (8% less than equimolar amount of NaOH) in the manner and under the conditions described in Example 1, and the sodium ampicillin was isolated in exactly the same manner as in Example 1.

Sources & evidence

ORD record
ord-177c8f38f14b4e4d99132f91365c0976
Source dataset
uspto-grants-1978_12
Patent number
US04130558

Reaction notes

Loading…