5-(2-Benzyloxy-4-iodophenyl)-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one → HCID 68839056, compound

HRID 660531Notes

Reaction equation

HRID 660531 reaction equation
[C:1]([O:5][C:6](=[O:16])[NH:7][C@@H:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C@H:9]1[CH2:14]I)([CH3:4])([CH3:3])[CH3:2].[CH2:17]([O:24][C:25]1[CH:30]=[C:29](I)[CH:28]=[CH:27][C:26]=1[N:32]1[S:36](=[O:38])(=[O:37])[N:35]([CH2:39][CH2:40][Si:41]([CH3:44])([CH3:43])[CH3:42])[C:34](=[O:45])[CH2:33]1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[C:1]([O:5][C:6](=[O:16])[NH:7][C@@H:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C@H:9]1[CH2:14][C:29]1[CH:28]=[CH:27][C:26]([N:32]2[CH2:33][C:34](=[O:45])[N:35]([CH2:39][CH2:40][Si:41]([CH3:44])([CH3:43])[CH3:42])[S:36]2(=[O:38])=[O:37])=[C:25]([O:24][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:30]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 667569375-(2-Benzyloxy-4-iodophenyl)-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-oneHCID 68870829HCID 68870829, compound

Product 1

HCID 68839056HCID 68839056, compound

Procedure

The title compound is prepared from ((1R*,2R*)-2-iodomethylcyclohexyl)-carbamic acid tert-butyl ester and 5-(2-benzyloxy-4-iodophenyl)-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one analogous to the method used in Example 57, step B.

Sources & evidence

ORD record
ord-3a462dca1111463886c6dcde98c37233
Source dataset
uspto-grants-2011_12
Patent number
US08084448B2

Reaction notes

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