Benzoyl chloride → HCID 68840001, compound

Participants

Reaction Steps

To a solution of 5-[4-(2-aminoethyl)-2-benzyloxyphenyl]-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one TFA salt (235 mg, 0.356 mmol) in methylene chloride (2 mL) is added triethylamine (0.1 mL) then benzoyl chloride (56 mg, 0.4 mmol) and the mixture is stirred at RT for 2 h. The solvent is removed under reduced pressure and 1 N HCl is added. The mixture is extracted with ether and the organic phase is dried over magnesium sulfate. The solvent is removed under reduced pressure and the residue is purified by flash chromatography using hexane/EtOAc (7:3) as eluent to give the title compound.

Provenance & Evidence