HRID66054

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14798

Sodium Hydroxide

HNaO

结构：CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccccc3)C(=O)N2[C@H]1C(=O)O.O.O.O

HCID23565

Ampicillin trihydrate

C16H25N3O7S

PRODUCTS

生成物

结构：CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccccc3)C(=O)N2[C@H]1C(=O)[O-].[Na+]

HCID23663979

Ampicillin sodium

C16H18N3NaO4S

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

PROCEDURE

实验过程

A suspension of 2.418 kg (6 mols) of ampicillin trihydrate in 15 liters of water was admixed with 300 ml of 2N sodium hydroxide, and the sodium ampicillin was isolated as a snow-white powder by lyophilization in the same manner and under the exact same conditions as in Example 1. The product was storage-stable and showed an active substance content of 91.5% in the microbiological test and 92.7% in the iodometric test.