5-(2-Benzyloxy-4-iodophenyl)-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one → HCID 68843325, compound

HRID 660556Notes

Reaction equation

HRID 660556 reaction equation
I[CH2:2][C@@H:3]1[CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5](=[O:13])[NH:4]1.[CH2:14]([O:21][C:22]1[CH:27]=[C:26](I)[CH:25]=[CH:24][C:23]=1[N:29]1[S:33](=[O:35])(=[O:34])[N:32]([CH2:36][CH2:37][Si:38]([CH3:41])([CH3:40])[CH3:39])[C:31](=[O:42])[CH2:30]1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[CH2:14]([O:21][C:22]1[CH:27]=[C:26]([CH:25]=[CH:24][C:23]=1[N:29]1[CH2:30][C:31](=[O:42])[N:32]([CH2:36][CH2:37][Si:38]([CH3:39])([CH3:40])[CH3:41])[S:33]1(=[O:34])=[O:35])[CH2:2][C@@H:3]1[CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5](=[O:13])[NH:4]1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

3

Reactant 2

HCID 667569375-(2-Benzyloxy-4-iodophenyl)-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-oneHCID 68842338HCID 68842338, compound

Product 1

HCID 68843325HCID 68843325, compound

Procedure

The title compound is prepared from (S)-3-iodomethyl-3,4-dihydro-2H-isoquinolin-1-one and 5-(2-benzyloxy-4-iodophenyl)-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one analogous to the method used in Example 57, step B.

Sources & evidence

ORD record
ord-533a1b8e7de846deb5655fab41a9b1dd
Source dataset
uspto-grants-2011_12
Patent number
US08084448B2

Reaction notes

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