1,8-Diazabicyclo(5.4.0)undec-7-ene → (R)-3-Hydroxymethyl-2,3-dihydrobenzo[c]azepin-1-one

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Reaction Steps

To a solution of 2-((R)-3-amino-4-hydroxy-but-1-enyl)-benzoic acid ethyl ester (1.8 g, 7.65 mmol) in 1:1 toluene/acetonitrile (4 mL) is added DBU (1 mL, 6.45 mmol) and stirred at RT for 18 h. The white precipitate is filtered to give the title compound: (M+1)+=190.

Provenance & Evidence