5-(2-Benzyloxy-4-iodophenyl)-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one → HCID 68923996, compound

HRID 660562Notes

Reaction equation

HRID 660562 reaction equation
I[CH2:2][C@@H:3]1[NH:9][C:8](=[O:10])[C:7]2[CH:11]=[CH:12][CH:13]=[CH:14][C:6]=2[CH:5]=[CH:4]1.[CH2:15]([O:22][C:23]1[CH:28]=[C:27](I)[CH:26]=[CH:25][C:24]=1[N:30]1[S:34](=[O:36])(=[O:35])[N:33]([CH2:37][CH2:38][Si:39]([CH3:42])([CH3:41])[CH3:40])[C:32](=[O:43])[CH2:31]1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[CH2:15]([O:22][C:23]1[CH:28]=[C:27]([CH:26]=[CH:25][C:24]=1[N:30]1[CH2:31][C:32](=[O:43])[N:33]([CH2:37][CH2:38][Si:39]([CH3:40])([CH3:41])[CH3:42])[S:34]1(=[O:35])=[O:36])[CH2:2][C@@H:3]1[NH:9][C:8](=[O:10])[C:7]2[CH:11]=[CH:12][CH:13]=[CH:14][C:6]=2[CH:5]=[CH:4]1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 667569375-(2-Benzyloxy-4-iodophenyl)-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-oneHCID 68838800HCID 68838800, compound

Product 1

HCID 68923996HCID 68923996, compound

Procedure

The title compound is prepared from (R)-3-iodomethyl-2,3-dihydrobenzo[c]azepin-1-one and 5-(2-benzyloxy-4-iodophenyl)-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one analogous to the method used in Example 57, step B.

Sources & evidence

ORD record
ord-2c901fb8421845bc9115aa3e81ca518e
Source dataset
uspto-grants-2011_12
Patent number
US08084448B2

Reaction notes

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