Boron tribromide → HCID 57777394, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (S)-3-[3-benzyloxy-4-(1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl)-benzyl]-2,3-dihydrobenzo[c]azepin-1-one in methylene chloride (2 mL) at −10° C. is added 0.3 mL of BBr3. The mixture is stirred at −10° C. for 30 min and is quenched with water. The aqueous phase is separated and lyophilized to give the title compound: 1H NMR (DMSO-d6) δ 9.61 (br s, 1H), 8.30 (d, J=5.56 Hz, 1H), 7.84 (d, J=7.58 Hz, 1H), 7.52 (t, J=7.07 Hz, 1H), 7.40 (t, J=7.58 Hz, 1H), 7.32 (d, J=8.0 Hz, 1H), 7.24 (d, J=8.08 Hz, 1H), 6.71 (m, 3H), 6.17 (m, 1H), 4.30 (s, 2H), 3.64 (m, 1H), 2.68 (m, 1H), 2.77 (m, 1H).

Provenance & Evidence