HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3,4-Dihydro-2-naphthyl)pyrrolidine → 1-[1-(3-Benzyloxy-4-nitrobenzyl)-3,4-dihydro-1H-naphthalen-2-ylidene]-pyrrolidinium Bromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3,4-Dihydro-2-naphthyl)pyrrolidine | HCID 88889 | — |
| Reactant | 2-Benzyloxy-4-bromomethyl-1-nitrobenzene | HCID 62115042 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 1-[1-(3-Benzyloxy-4-nitrobenzyl)-3,4-dihydro-1H-naphthalen-2-ylidene]-pyrrolidinium Bromide | HCID 68839033 | — |
Reaction Steps
A solution of 1-(3,4-dihydronaphthalen-2-yl)-pyrrolidine (Syn. Comm. 33, 2215 (2003)) (450 mg, 2.26 mmol) and 2-benzyloxy-4-bromomethyl-1-nitrobenzene (Example 83, step C) (730 mg, 2.26 mmol) in 20 mL CH3CN is stirred at RT for 1 h. The solvent is removed under reduced pressure to give the title compound as a red solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08084448B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-758fed7dc0a445afa06c0341aa628cee |
| Source note | uspto-grants-2011_12 |