HuagongsheHuagongshe Chemistry Print Report · For research reference only
Azobisisobutyronitrile → Bromo-(2-iodophenyl)-acetic Acid Methyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Azobisisobutyronitrile | HCID 6547 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | Methyl 2-(2-iodophenyl)acetate | HCID 640185 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | Bromo-(2-iodophenyl)-acetic Acid Methyl Ester | HCID 86632576 | — |
Reaction Steps
A mixture of (2-iodophenyl)-acetic acid methyl ester (14.5 g, 52.5 mmol), NBS (18.7 g, 105 mmol) and AIBN (1.72 g, 10.5 mmol) in CCl4 (300 mL) is refluxed for 10 h. The mixture is cooled to RT and the precipitate filtered. The filtrate is evaporated to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08084448B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-db93df6fcc214a318294e7c39ea96e68 |
| Source note | uspto-grants-2011_12 |