HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 660574Generated: October 27, 2026
Methanesulfonyl chloride → Methanesulfonic Acid 7-oxo-6,7-dihydro-5H-dibenzo[c,e]azepin-5-ylmethyl Ester
https://huagongshe.com/reaction/660574
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | 7-Hydroxymethyl-6,7-dihydrodibenzo[c,e]azepin-5-one | HCID 68842223 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | Methanesulfonic Acid 7-oxo-6,7-dihydro-5H-dibenzo[c,e]azepin-5-ylmethyl Ester | HCID 86632578 | — |
Reaction Steps
To a solution of 7-hydroxymethyl-6,7-dihydro-dibenzo[c,e]azepin-5-one in pyridine (2 mL) at 0° C. is added MsCl. The mixture is stirred at 0° C. for 20 min then is quenched with ice/water. The mixture is extracted with EtOAc and the organic phase is dried over magnesium sulfate and the solvent is removed under reduced pressure to give the title compound which is used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08084448B2 |
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| Source dataset | uspto-grants-2011_12 |
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| ORD ID | ord-7081c40d9be94a18a2631c814b29cef3 |
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| Source note | uspto-grants-2011_12 |
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