5-(2-Benzyloxy-4-iodophenyl)-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one → 7-{3-Benzyloxy-4-[1,1,4-trioxo-5-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-2-yl]-benzyl}-6,7-dihydro-dibenzo[c,e]azepin-5-one

HRID 660576Notes

Reaction equation

HRID 660576 reaction equation
I[CH2:2][CH:3]1[NH:9][C:8](=[O:10])[C:7]2[CH:11]=[CH:12][CH:13]=[CH:14][C:6]=2[C:5]2[CH:15]=[CH:16][CH:17]=[CH:18][C:4]1=2.[CH2:19]([O:26][C:27]1[CH:32]=[C:31](I)[CH:30]=[CH:29][C:28]=1[N:34]1[S:38](=[O:40])(=[O:39])[N:37]([CH2:41][CH2:42][Si:43]([CH3:46])([CH3:45])[CH3:44])[C:36](=[O:47])[CH2:35]1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[CH2:19]([O:26][C:27]1[CH:32]=[C:31]([CH:30]=[CH:29][C:28]=1[N:34]1[CH2:35][C:36](=[O:47])[N:37]([CH2:41][CH2:42][Si:43]([CH3:44])([CH3:45])[CH3:46])[S:38]1(=[O:39])=[O:40])[CH2:2][CH:3]1[NH:9][C:8](=[O:10])[C:7]2[CH:11]=[CH:12][CH:13]=[CH:14][C:6]=2[C:5]2[CH:15]=[CH:16][CH:17]=[CH:18][C:4]1=2)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 667569375-(2-Benzyloxy-4-iodophenyl)-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-oneHCID 688399527-Iodomethyl-6,7-dihydro-dibenzo[c,e]azepin-5-one

Product 1

HCID 688399547-{3-Benzyloxy-4-[1,1,4-trioxo-5-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-2-yl]-benzyl}-6,7-dihydro-dibenzo[c,e]azepin-5-one

Procedure

The title compound is prepared from 7-iodomethyl-6,7-dihydro-dibenzo[c,e]azepin-5-one and 5-(2-benzyloxy-4-iodophenyl)-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one analogous to the method used in Example 57, step B.

Sources & evidence

ORD record
ord-cddfe798c57540cfba99c0e93796d91c
Source dataset
uspto-grants-2011_12
Patent number
US08084448B2

Reaction notes

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