HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Nitro-(3-oxo-1H,3H-benzo[de]isochromen-1-yl)-acetic Acid Methyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Methyl 2-nitroacetate | HCID 17206 | — |
| Reactant | Methyl 8-formylnaphthalene-1-carboxylate | HCID 349031 | — |
| Catalyst | Piperidine | HCID 8082 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Nitro-(3-oxo-1H,3H-benzo[de]isochromen-1-yl)-acetic Acid Methyl Ester | HCID 86632579 | — |
Reaction Steps
To a solution of 8-formylnaphthalene-1-carboxylic acid methyl ester (2.5 g, 11.68 mmol) in EtOH (20 mL) is added 8 drops of piperidine followed by nitroacetic acid methyl ester (2.78 g, 23.4 mmol) and the mixture is stirred at RT for 20 h. Ethyl acetate is added followed by 1N HCl. The resulting precipitate is filtered to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08084448B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-9c1c9066a5de4d7fb35bfb62bd785215 |
| Source note | uspto-grants-2011_12 |