HCID 68839056, compound → HCID 68839756, compound

HRID 660585Notes

Reaction equation

HRID 660585 reaction equation
C(OC(=O)[NH:7][C@@H:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C@H:9]1[CH2:14][C:15]1[CH:20]=[CH:19][C:18]([N:21]2[CH2:25][C:24](=[O:26])[N:23]([CH2:27][CH2:28][Si:29]([CH3:32])([CH3:31])[CH3:30])[S:22]2(=[O:34])=[O:33])=[C:17]([O:35][CH2:36][C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)[CH:16]=1)(C)(C)C>C(O)(C(F)(F)F)=O.C(Cl)Cl>[NH2:7][C@@H:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C@H:9]1[CH2:14][C:15]1[CH:20]=[CH:19][C:18]([N:21]2[S:22](=[O:34])(=[O:33])[N:23]([CH2:27][CH2:28][Si:29]([CH3:31])([CH3:32])[CH3:30])[C:24](=[O:26])[CH2:25]2)=[C:17]([O:35][CH2:36][C:37]2[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=2)[CH:16]=1

Participants

3

Reactant 1

HCID 68839056HCID 68839056, compound

Product 1

HCID 68839756HCID 68839756, compound

Reagents, catalysts & solvents 1

HCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

A solution of ((1R*,2S*)-2-{3-benzyloxy-4-[1,1,4-trioxo-5-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-2-yl]-benzyl}-cyclohexyl)-carbamic acid tert-butyl ester (Example 66, step C) (150 mg, 0.238 mmol) in 2 mL of TFA/methylene chloride (1:1) is stirred at RT for 15 min. The solvent is removed under reduced pressure to give the title compound which is used directly in the next step.

Workup

  1. customThe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-ecfa89818c9c4f91a1cca494fd6f6ef7
Source dataset
uspto-grants-2011_12
Patent number
US08084448B2

Reaction notes

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