HCID 68838974, compound → HCID 57777379, compound

Participants

Reaction Steps

A mixture of 3-[3-benzyloxy-4-(1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl)-phenyl]-N-isopropyl-N-methylpropionamide (0.06 g) and 10% Pd/C (0.03 g) in EtOAc (25 mL) is hydrogenated at 1 atm for 18 h. The catalyst is filtered through Celite and the solvent is removed under reduced pressure. The residual gum is purified by preparative HPLC to afford the title compound as a grey solid: 1H NMR (DMSO-d6□7.21 (d, J=8.08 Hz, 1H), 6.73 (s, 1H), 6.66 (d, J=8.08 Hz, 1H), 4.71-4.64 (m, 0.65H), 4.23 (s, 2H), 4.10-4.02 (m, 0.35H), 2.72 (s, 2H), 2.73-2.54 (m, 4H), 2.64 (s, 1H), 1.07 (d, J=6.57 Hz, 2.5H), 0.99 (d, J=6.57 Hz, 3.5H); (M−1)−=354.

Provenance & Evidence