1,2,3,4-Tetrahydroisoquinoline → HCID 42629663, compound

HRID 660598Notes

Reaction equation

HRID 660598 reaction equation
C([O:8][C:9]1[CH:10]=[C:11]([CH2:29][CH2:30][C:31]([OH:33])=O)[CH:12]=[CH:13][C:14]=1[N:15]1[CH2:19][C:18](=[O:20])[N:17](CC[Si](C)(C)C)[S:16]1(=[O:28])=[O:27])C1C=CC=CC=1.[CH2:34]1[C:43]2[C:38](=[CH:39][CH:40]=[CH:41][CH:42]=2)[CH2:37][CH2:36][NH:35]1>>[CH2:34]1[C:43]2[C:38](=[CH:39][CH:40]=[CH:41][CH:42]=2)[CH2:37][CH2:36][N:35]1[C:31](=[O:33])[CH2:30][CH2:29][C:11]1[CH:12]=[CH:13][C:14]([N:15]2[S:16](=[O:27])(=[O:28])[NH:17][C:18](=[O:20])[CH2:19]2)=[C:9]([OH:8])[CH:10]=1

Participants

3

Reactant 2

HCID 70461,2,3,4-TetrahydroisoquinolineHCID 68839806HCID 68839806, compound

Product 1

HCID 42629663HCID 42629663, compound

Procedure

The title compound is prepared from 3-{3-benzyloxy-4-[1,1,4-trioxo-5-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-2-yl]-phenyl}-propionic acid and tetrahydroisoquinoline analogous to Example 97, steps D, E and F: (M−1)−=414.

Sources & evidence

ORD record
ord-17579150744548ebb84c11625ab49b9b
Source dataset
uspto-grants-2011_12
Patent number
US08084448B2

Reaction notes

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